A Study of the Behavior of Fowl Pox Virus Modified by Intracerebral Passage
نویسنده
چکیده
1. Intracerebral transfer in chicks of fowl pox virus produces marked changes in its behavior when studied in the chorio-allantoic membrane of chick embryos and in the skin of baby chicks. 2. A great and persistent increase in virulence for epithelial cells, characterized by rapid necrosis instead of proliferation and hyperplasia, is acquired by the virus propagated intracerebrally. 3. An affinity for cells of mesodermal origin including endothelial cells of blood vessels, and an increase in affinity for entodermal cells is acquired by the virus propagated intracerebrally. 4. The intracerebral virus causes a uniform morphological change in all types of cells, in that the infected cells rapidly become spherical in shape, detached, and desquamated followed by necrosis. 5. One intracerebral passage is sufficient to produce this change in the virus.
منابع مشابه
A Meningo-encephalitis in Chicks Produced by the Intracerebral Injection of Fowl Pox Virus
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Fowl pox is a viral disease of domestic and wild birds. The large size of the genome makes it a useful vector for recombinant DNA technology. Although the disease has been described in both commercial and indigenous chickens in Nigeria, data are limited on seroprevalence in free range chickens. Such data are, however, important in the design and implementation of fowl pox virus vector vaccine. ...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 67 شماره
صفحات -
تاریخ انتشار 1938